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Thirai Sorgam > Reproductive Health > Josh Duhamel takes testosterone replacement therapy at 52 for younger wife — what men should know about it
Reproductive Health

Josh Duhamel takes testosterone replacement therapy at 52 for younger wife — what men should know about it

June 21, 2025 5 Min Read
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Josh Duhamel takes testosterone replacement therapy at 52 for younger wife — what men should know about it
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52-year-old American actor Josh Duhamel is undergoing testosterone replacement therapy to maintain vitality. Health experts warn that this hormone therapy should be medically supervised.

52-year-old American actor Josh Duhamel has not built his bones about revealing that he has started testosterone replacement therapy to maintain his “malignant” for his 31-year-old wife Audra Mali. The “Transformers” actor acknowledged that his decision was driven by medical results showing low testosterone levels, which had a positive effect on his energy levels in general. However, doctors warn that this treatment is not for everyone and not for general fitness or anti-aging purposes.

According to People.com, Duhamel said his wife was one of the factors that led him to start hormone replacement therapy. “For her, it’s important to be as young as possible and upset as possible,” the actor said of his wife, whom he married in 2022.

Josh Duhamel on the Benefits of Testosterone Replacement Therapy

His intimate life has influenced testosterone replacement therapy in a positive way to other aspects of his life. Duhamel said: “I think there’s overall health. Just having that energy, you want to go out and achieve, you want to be a better brother, you want to be a better brother, you become a better friend, you become a better business owner, you don’t tapere normally.

Josh Duhamel is the father of two. He has ex-wife Fergie and an 11-year-old son named Axl, Mari and his son Shepherd (1).

The Josh Duhamel family
with Josh Duhamel, his wife Audrey and his one-year-old son. Image provided by: Instagram/ Josh Duhamel

Speaking about what really encouraged him to consider testosterone replacement therapy, he said: “I’ve been listening to this for a while. It was one of those things I didn’t want to talk about. It wasn’t anyone asking about it either. That’s when I decided to start it.”

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He claims that his physical strength has improved and that he has changed his world. “I literally got my mojo back, and now it’s around for my kids and not about its aesthetics as much as I can roll around the dirt with them as I was when I was younger,” he said.

Kate Winslet Guarantee for Testosterone Therapy to Increase Sex Drive

What is testosterone replacement therapy?

Testosterone replacement therapy (TRT) is a medical treatment used in men with very low testosterone levels due to their health.

“It helps to improve energy, libido, mood and strength. However, it is important to understand that TRT is not intended for the general fitness or anti-aging purpose of healthy individuals. If used without proper diagnosis and monitoring, it can cause serious side effects.

What are the side effects of TRT?

According to Dr. Kandula, TRT reduces sperm count and can lead to infertility. It can also cause abnormal increases in red blood cell levels, increasing the risk of blood clots. In men who are already at high risk for prostate cancer, TRT can promote cancer growth. “That’s why it’s very important to have a blood test and a prostate screening before starting this treatment,” he added.

Sexual Medicine consultant Dr. Aninda Sidana says improving energy levels through testosterone replacement therapy is merely a placebo effect.

“Sexual performance and vitality don’t depend solely on testosterone levels. There are multiple chemicals that also play a role in erectile dysfunction and reduced sexual performance. Lifestyle factors are far more important.
Support for TRT for increased intimacy and (sexual compatibility) can lead to misuse of testosterone supplements by men to improve performance,” Sidhana tells HealthShot.

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This treatment should be used constantly under the care of a specialist, such as an endocrinologist, and using regular follow-up tests to ensure safety and efficacy.

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